SLC39A6 and neoplasm: In present study, we observed results as following: 1) LIV-1 expression was more high in three liver cancer cell lines compared with normal liver cells.The transcription level of LIV-1 was higher in human liver cancer compared with normal tissues; 2) 61% liver carcinoma tissues expressed higher LIV-1 protein than the normal tissues and LIV-1 expression was associated with tumor size and lymphnode metastases or microscopic vascular invasion; 3) down-regulation of LIV-1 in liver cancer cells led to inhibition of cell growth both in vitro and in vivo.