It is suggested that osteopontin plays a role in many diseases such as chronic inflammation, including Crohn’s disease [33], several types of cancer [34]–[36], autoimmune diseases [37], [38] i.e. Grave’s disease [39], obesity [40], [41], atherosclerosis [40]–[48] and cardiac fibrosis [40]. The gene discussed is SPP1; the disease is autoimmune disease.