Data of our study showed that majority of hyperthyroid patients (69.2%) were diagnosed as Grave’s disease but we cannot state with confidence that this is the only thyroid dysfunction responsible for deranged osteopontin levels because similar results were obtained in all other cases of hyperthyroidism i.e. toxic adenoma (5.41%) and toxic nodular goiter (14%). Here, SPP1 is linked to toxic multinodular goitre.