In contrast to our findings, Thraikill et al. reported on a positive effect of OC on endogenous insulin production (assessed by authors as C-peptide/glucose ratio) [34], but several differences in term of sample size, population (new-onset vs. long-standing diabetes), design of the study (longitudinal vs. cross-sectional) and measure of endogenous insulin production (C-peptide vs. C-peptide/glucose ratio) limit the comparison between our study and the one conducted by Thraikill. Here, INS is linked to diabetes mellitus.