A large variety of mechanisms have been proposed to explain this finding, (such as hyperglycemia, inflammation and generation of advanced-glycation end products into the bone matrix), but most studies have focused on the lack of anabolic effect of insulin on osteoblasts, indicating T1D as a condition of low bone turnover, meaning both osteoblast and osteoclast functions are suppressed [4], [5], [6]. Here, INS is linked to type 1 diabetes mellitus.