The ability of selective Akt inhibitors to positively combine with FLT3 inhibitors against mutant FLT3-positive AML cells in the presence of RPMI+10% FBS correlated well with induction of apoptosis, as the combination of PKC412 and KIN001-102 showed the highest percentages of cell killing as compared to single agent effects (Table 2 and Figure S7 Part I and II). The gene discussed is FLT3; the disease is acute myeloid leukemia.