In previous studies, a mouse model of schistosomiasis, which has Th2 cytokine driven pathology, showed that TSLP signaling was involved in the development of polarized Th2 cytokine response during a primary response, but TSLP was dispensable for the formation of Th2-dependent pathology during a chronic S. mansoni infection [43]. Here, TSLP is linked to schistosomiasis.