Importance of diet and role of TNF-α in atherosclerosis progression was further substantiated by a study in which the authors showed that ApoE−/−/TNF-α−/− double knockout mice had a 50% reduction in lesion size relative to ApoE−/− single knockouts when put on ‘Western-style’ high-fat diet [3]. The gene discussed is TNF; the disease is atherosclerosis.