As there currently are no data available on the expression of VEGF-D or VEGF-R3 in angiomylipomoma tissues or cells, additional studies are needed to understand the importance of VEGF-D/VEGF-R3 interactions relevant to the development and progression of this prominent feature of tuberous sclerosis and sporadic LAM. This evidence concerns the gene VEGFD and lymphangioleiomyomatosis.