[1], [2] After hepatitis B e antigen (HBeAg) seroconversion, patients usually enter the inactive state, with low viral load and normal alanine aminotransferase (ALT) level. However, a certain proportion of inactive carriers may experience HBV reactivation, which accelerates the disease progression to end-stage liver disease, including cirrhosis and hepatocellular carcinoma (HCC). [3] Therefore, patients in the HBeAg-negative phase should still receive regular monitoring of the hepatitis activity. This evidence concerns the gene GPT and Cirrhosis.