ACTA1 and nemaline myopathy: A prime example is nemaline myopathy (NM), the most common non-dystrophic congenital skeletal muscle myopathy [30] that is caused by mutations in six genes that all encode thin filament proteins (TMP2 [31], TMP3 [32], NEB [33], ACTA1 [34], TNNT1 [35], CFL2 [36]).