NEB and nemaline myopathy: A reduction in the number of force generating crossbridges was previously reported in nebulin-deficient muscle both in the mouse KO model and in NM patients [2]; this finding might underlie the larger effect of CK-2066260 at maximal activation on both ktr (increase 9% in WT and 34% in KO) and Tmax (increase 13% in WT and 30% in KO).