BMI1 and neoplasm: Necropsies performed in animals 28 days following injection of Bmi1 expressing MiaPaCa2 cells revealed gross metastasis of tumor to extra-pancreatic sites, including the peritoneum, liver and bowel in (3/5 animals, Figure 4B), while no gross metastatic deposits (0/5) observed in mice injected with wild type MiaPaCa2 cells at 28 days (Table 1).