SOCS1 and cancer: A previous study focusing on DNA methylation profiles in HCC at a few selected loci of tumor suppressor genes and oncogenes found methylation changes in the promoters of 9 cancer-related genes, including SOCS-1, GSTP, APC, E-cadherin, RAR-beta, p14, p15, p16 (CDKN2A), and p73[19].