Table 3 shows the frequencies of individuals with various genotypes and alleles at the SAA1 locus in either FMF patients (n = 83) or Japanese healthy subjects (n = 200). The allele frequency of SAA1.1 was significantly lower in FMF patients compared with healthy subjects (21.7% versus 34.0%). Conversely, the allele frequency of SAA1.3 was higher in FMF patients compared with healthy subjects (48.8% versus 37.5%). This evidence concerns the gene SAA1 and familial Mediterranean fever.