AA amyloidosis was histologically confirmed in 4 patients with FMF, whose genotypes were M694I/M694I SAA1.5/15, M694I/E148Q/L110P SAA1.1/1.1, M694I/E148Q/L110P SAA1.3/1.5 and E148Q/R202Q/P369S/R408Q SAA1.3/1.5. The gene discussed is SAA1; the disease is familial Mediterranean fever.