Taken together these data indicate that ROS modifiers, such as overexpression of catalase that converts hydrogen peroxide to water or a glutathione peroxidase mimic-Ebselen that modulates oxidative stress by enhancing thioredoxin reductase activity in 4-OH-E2-transformed MCF10AT cells is sufficient to inhibit xenograft growth of adenocarcinoma. The gene discussed is CAT; the disease is adenocarcinoma.