HMGB1 and Other metabolic disease: In that regard, we previously described neutrophil-rich inflammation and a high frequency of cell death in pulmonary TB lesions of diabetic and hypercholesterolemic mice that express IFN-γ to an equal or greater extent than mice without metabolic disorders [30], [35], [36], and we showed that HMGB1 is released in the course of Mtb burst size cytolysis [37].