Nevertheless, irrespective of whether or not the infecting virus expresses functional EBNA3C (WT-BAC, EBNA3C-revertant or 3CHT plus 4HT) or is EBNA3C-deficient (EBNA3CKO or 3CHT minus 4HT), during the first few days post-infection there is a substantial increase in transcripts corresponding to INK4a/CDKN2A. This evidence concerns the gene CDKN2A and infection.