Albeit, presently, no CTR-induced activation of NF-κB or IFN regulatory factor 3 (IRF3) and subsequent IFN production has been shown during virus infection; CLR may induce signaling via a number of kinases, including spleen tyrosin kinase (SYK) and Src kinase during bacterial and virus infections; thus, CLRs possibly shape innate responses during infection [72]. This evidence concerns the gene CALCR and viral infectious disease.