PIK3CA and neoplasm: Although the limited number of patients prevents definitive conclusions, it was noted that all five patients with molecular aberrations (EGFR mutations L848R and G873E and PIK3CA mutation E542K (n=1), EGFR exon 20 insertion (n=1), EGFR exon 19 deletion (n=1), p53 mutation (n=1), PIK3CA mutation (n=1)) experienced tumor regression, which in some cases was prolonged.