EGFR and cancer: The Ras family, containing H-(or Ha-) Ras, K-(or Ki-) Ras, and N-Ras, which transmits extracellular signals to the interior of the cells via switching the inactive GDP-bound state to the active GTP-bound state, are commonly thought of as oncogenes; the Ras/Raf/MEK/MAPK pathway is thought to be functional downstream of EGFR (Epidermal growth-factor receptor), which has been associated with a more aggressive disease or poor prognosis in variety of cancer systems including lung cancer [8,9].