Furthermore, clinical trials showed that combining gemcitabine-based chemotherapy with EGFR inhibitors in NSCLC have not produced a survival advantage, and the in vitro findings indicated that balance between gemcitabine-induced and AG1478 (one of EGFR inhibitors)-inhibited ERK phosphorylation may have effects [13]. This evidence concerns the gene MAPK1 and non-small cell lung carcinoma.