POU5F1 and neoplasm: Compared with the control group, adenovirus with Dual-shRNA exerted the strongest inhibitory effect on tumor growth because the tumor inhibitory rate was 67.59% (P = 0.0001) compared to 44.54% (P = 0.0020) and 25.25% (P = 0.0418) in the OCT4-shRNA and BIRC5-shRNA groups, respectively (Figure 6A).