Therefore, multiple strategies have been employed to target BIRC5 for cancer therapy by silencing BIRC5 expression with small interfering RNA [23] or antisense oligonucleotides [24], inhibiting the BIRC5 promoter activity with small-molecule antagonists [25], and interfering BIRC5 function with dominant-negative mutant forms of the protein [26]. Here, BIRC5 is linked to cancer.