Malaria vector resistance to insecticides in Cameroon is conferred by two main mechanisms: (1) an increase of detoxification and/or metabolism through high levels of multi-function oxidases (MFOs), glutathione S-transferases (GSTs) and non-specific esterases (NSEs)[12,13] and (2) alterations at site of action in the sodium channel, viz the kdr mutations[11,14]. This evidence concerns the gene HPGDS and malaria.