Moreover, in the group of individuals that succumbed to infection and died, TNF, ALT, HO-1, SOD-1, IL-10, IFN-γ and indirect bilirubin displayed more connectivity with other biomarkers, which caused a small increase in the complexity of the network when compared to the group of individuals with non-lethal severe malaria (Figure 1). The gene discussed is SOD1; the disease is malaria.