IL1B and infection: In those individuals in which infection did not lead to the onset of symptoms, the number of significant interactions was similar to the group of non-infected people (19 significant hits in the group of uninfected individuals and 18 hits in asymptomatic malaria), but the number of associations involving mainly IL-4 and to a lesser extent IL-1β was greatly increased in these individuals, leading to a totally different pattern of connectivity in the network (Figure 1).