For instance, a comparative study of Sirt3 wild-type and knockout mice has shown that SIRT3 mediates the beneficial effects of DR on age-related hearing loss and prevents the accumulation of ROS under DR in cochlea cells through the deacetylation and activation of isocitrate dehydrogenase 2 (IDH2) 70. The gene discussed is SIRT3; the disease is presbycusis.