in a significantly larger cohort of PSP-CBS cases and to quantitatively assess tau distribution in more cortical regions and other brain regions including the basal ganglia, brainstem and cerebellum; (ii) to determine the cellular lesions which contribute to the tau pathology were characteristic of PSP pathology rather than Alzheimer-type neurofibrillary tangle pathology; and (iii) to assess neuronal loss of the substantia nigra and subthalamic nuclei and pathological involvement of the corticospinal tract. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.