MAPT and supranuclear palsy, progressive, 1: We speculate that the total tau pathology may inversely correlate with the disease duration in PSP variants and while the ‘brainstem’ PSP variant appears to be a more ‘benign’ form of PSP, the ‘cortical’ PSP variant represents a deviation from the classical presentation determined by a shift of tau pathology from the basal ganglia to the cerebral cortex.