Because phosphatidylinositol-3 kinase (PI3K) and serine-threonine protein kinase AKT (also known as protein kinase B) seem to make immune cell activation by regulation of the key inflammatory cytokines [13], changes in PI3K/AKT signaling pathway may contribute to specific therapeutic effects for the NAFLD. Here, AKT1 is linked to metabolic dysfunction-associated steatotic liver disease.