On the one hand, miR-29a and miR-29b are downregulated in mantle cell lymphoma [583], aggressive CLL samples (high ZAP-70 with unmutated IgVH) [659, 710, 716], ALK-positive anaplastic large cell lymphomas (ALCL) [380], MM [381], and AML [383]. The gene discussed is ZAP70; the disease is B-cell chronic lymphocytic leukemia.