NOTCH1 and T-cell acute lymphoblastic leukemia: Acute lymphoblastic T-cell leukemia is frequently associated with increased Notch signaling [75–79], which may be caused by the chromosomal translocation t(7; 9)(q34; q34.3) [80], gain-of-function mutations of Notch1 [81], and/or mutations in Fbw7 (F-box and WD repeat domain-containing 7), a negative regulator of Notch1 [82].