CDK6 and neoplasm: A third miRNA downregulated by c-Myc is the tumor suppressor let-7 miRNA cluster [473], which targets, among others, the Ras oncogene [476], HMGA2 (high mobility group A2) [477, 478], Bcl-XL [361], Cdc25A, CDK6 (cyclin-dependent kinase 6), and cyclin D2 [479].