PDK1 and breast carcinoma: Similarly, treatment of 3 μM γ-tocotrienol, 6.4 μM GW9662 or 6.4 μM T0070907 alone had little or no effect on intracellular levels of phospho-Akt (activated), PDK-1, PI3K, Akt, PTEN, and phospho-PTEN in MDA-MB-231 breast cancer cells, as compared to vehicle-treated controls (Figure 10(b)).