PPARG and breast cancer: Combined treatment of γ-tocotrienol with PPARγ agonists, rosiglitazone, and troglitazone was found to be statistically antagonistic on MCF-7 (Figure 4(a)) and MDA-MB-231 (Figure 4(b)) breast cancer cell growth, as evidenced by the location of the data point in the isobologram being well above the line defining additive effect.