Recent studies have shown that tocotrienols activate specific PPARs in reporter-based assays [21], whereas other studies have shown that γ-tocotrienol increases intracellular levels of 15-lipoxygenase-2, the enzyme responsible for the conversion of arachidonic acid to the PPARγ activating ligand, 15-S-hydroxyeicosatrienooic acid, in prostate cancer cells [22]. This evidence concerns the gene PPARG and Familial prostate cancer.