HTR1A and sexual dysfunction: At present, the evidence relating to the effects of drugs acting on the 5-HT1A receptor is intriguing: the partial agonist buspirone has been used to reduce sexual dysfunction associated with selective serotonin reuptake inhibitors [64, 65], and the partial agonist gepirone improves sexual functioning in depressed men, independent of antidepressant or anxiolytic effects [66].