CRP and obesity due to melanocortin 4 receptor deficiency: Obesity is associated with low-grade chronic inflammation and adipose tissue is a main source of excess production of cytokines like tumour necrosis factor-α (TNF-α), interleukin-18 (IL-18), IL-1, IL-8, monocyte chemoattractant protein-1, and C reactive protein (CRP) [96].