IFNA1 and viral infectious disease: The type I IFNs (primarily IFNα/β), produced in a direct response to virus infection, bind to the common IFNα/β receptor (IFNAR1/IFNAR2c), inducing receptor dimerization, phosphorylation and subsequent phosphorylation of receptor-associated Janus kinases (Jaks), Jak1 and Tyk2.