BDNF and obesity due to melanocortin 4 receptor deficiency: A published case report describes a de novo chromosomal inversion, 46,XX,inv(11)(p13p15.3) (a region encompassing the BDNF gene) in an 8-year-old girl with hyperphagia, severe obesity, impaired cognitive function, hyperactivity and low serum concentration of BDNF protein [37].