FLT3 and acute myeloid leukemia: Of note, while the thresholds used for the calculation of the impact on survival varied in each of the studies [2], [4], [12], our data shows homogeneity of signaling in AML samples starting with ∼40% FLT3 ITD (Fig. 2), a value currently used to define high risk status in pediatric AML by the Childrens Oncology Group [55].