FLT3 and acute myeloid leukemia: FMS-like tyrosine kinase 3 receptor (FLT3) receptor mutations are among the most common somatic mutations in acute myeloid leukemia (AML), with FLT3 internal tandem duplications (ITDs) occurring in 20–35% of adult AML [1], [2], [3], [4], [5], [6], [7] and ∼5–15% of pediatric AML [8], [9], [10].