In addition, serum Klotho was also a significant predictor of arterial stiffness in the full model including confounders such as age, MBP, diabetes mellitus, dyslipidemia, eGFR, albuminuria, phosphate, PTH, 1,25D and FGF23, and the adjusted odds ratio (OR) for serum Klotho (per 100 pg/mL increase) was 0.60 (95% CI: 0.39 to 0.98; p = 0.0075). This evidence concerns the gene FGF23 and metabolic syndrome.