The association between MTHFR C677T polymorphism and cervical cancer risk was first reported in a mixed populations by Piyathilake et al [22]; however, as discussed above, conflicting data regarding the role of MTHFR in cervical cancer susceptibility and presentation have been reported by series of case-control studies [11]–[14], [16], [18]–[21]. This evidence concerns the gene MTHFR and cervical carcinoma.