PPARA and metabolic dysfunction-associated steatohepatitis: The evaluation of the impact of PPAR variants on (1) the susceptibility to NASH in specific subgroup of patients such as severely obese subjects in adequately powered studies and (2) on the response to drugs targeting PPARs (such as glitazones or PPARα/δ agonists, which are under study in NASH patients), represent promising new areas of investigation.