The frequency of this SNP did not differ between patients and controls, but the presence of the PPARα 162Val allele was associated with higher IR, but not histologically assessed disease severity [25], suggesting that the risk related to increased IR may be balanced by the protective effect of decreased oxidative stress, the other key player in the progression of liver disease in patients with NASH. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.