In 79 NAFLD patients and 63 healthy controls, it was found that the PPARα Val227Ala genotype frequency was significantly different between NAFLD and control subjects and that the fat-related index such as weight, body mass index (BMI), hip circumference, waist circumference, waist-to-hip ratio, and the percentage of body fat of the carriers of the Ala227 allele was lower than that in noncarriers [24]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.