ERBB2 and breast cancer: On the other hand, key cancer-related oncogenes type I receptor tyrosine kinase HER2- (erbB-2-) dependent endogenous fatty acid (FA) constitutive upregulation and biogenesis catalyzed by lipogenic enzymes such as fatty acid synthase (FASN) [76, 77], constitutes an oncogenic stimulus that drives normal epithelial cells progression toward malignancyand has been reported to provide a “lipogenic benefit” in terms of enhanced breast cancer cell proliferation, survival, chemoresistance, and metastasis [78].