PPARG and type 2 diabetes mellitus: PPARγ activators are commonly used to treat patients with type 2 diabetes who share metabolic abnormalities including excessive and inflamed adipose tissue [74], particularly in visceral depots [75], elevated circulating concentrations of nonesterified fatty acids (NEFA), triglycerides, glucose, insulin, and inflammatory mediators and reduced concentrations of adiponectin and high-density lipoprotein cholesterol (HDL-C).