Subjects with dysregulated glucose showed a median change of 0 with increased ranges: IGT over 56 days (−0.3 to 0.4% Hb), metformin T2DM over 112 days (−2.2 to 2.0% Hb), and treatment-naïve T2DM over 112 days (−3.4 to 2.8% Hb). The gene discussed is GSTM1; the disease is type 2 diabetes mellitus.