CD4+ TH1 cells may progress stroke through releasing proinflammatory cytokines, including IL-2, IL-12, IFN-γ, and TNF-α, whereas CD4+ TH2 cells may play a protective role through releasing anti-inflammatory cytokines such as IL-4, IL-5, IL-10, and IL-13 [34]. The gene discussed is CD4; the disease is Stroke.