Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin were observed to be increased both in large intracranial artery disease and small-artery disease [4], and plasma levels of ICAM-1 and monocyte chemoattractant protein-1 (MCP-1) were noted to be high in patients with ischemic stroke and myocardial infarction [5, 6]. Here, CCL2 is linked to ischemic stroke.