Our results showed that PD was able to robustly inhibit the expression of iNOS and COX-2 protein mediated by CLP in a dose-dependent manner, which was in line with its protection on septic lung injury, indicating that the protective effects of PD on sepsis-induced lung injury might be by inhibiting COX-2/PGE2 and iNOS/NO pathways. The gene discussed is NOS2; the disease is Sepsis.