PKCζ is a conserved, atypical isoform of PKC that contributes to various functions in metazoans, ranging from cell polarity and migration to innate responses to infection (Xu and Clark, 1997; Laudanna et al., 1998; Feng and Longmore, 2005; Nishimura et al., 2005). The gene discussed is PRRT2; the disease is infection.