AGPAT2 and Insulin resistance: The recentdemonstration that, as in humans, Agpat2 deficiency in mice produces generalisedlipodystrophy and severe insulin resistance provides an in vivo model for furtherinvestigations (Cortes et al. 2009).AGPAT2 loss may alter the generation of lipid species that can directly or indirectlyplay a role in modulating gene transcription.