A study of systemic levels of 120 mediators in allotransplanted patients with acute GVHD, including the chemokines CCL2, CCL3, CCL5, CCL7, CCL8, CCL11, CCL13 and CXCL10 together with other cytokines, soluble receptors and adhesion molecules [82]. Four markers of particular importance were identified as markers of acute GVHD. This evidence concerns the gene CCL8 and acute graft versus host disease.