CXCR1 and graft versus host disease: CXCL8 is important, both for development of angiogenesis and for T-cell chemotaxis [42,117]; CXCR1/CXCR2 inhibition may thus have several beneficial effects in these patients, including (i) inhibition of GVHD associated angiogenesis; (ii) inhibition of T-cell recruitment to GVHD-affected organs and (iii) possibly an antileukemic effect with reduction of posttransplant relapse risk through inhibition of local angiogenesis induced by residual leukemia cells.