A complex series of experiments followed in which the granuloma inducing properties of T cells were attributed to TH cells, while granuloma and SEA-induced suppressive effects were attributed to both the TH and CD8+ cytotoxic T lymphocyte (CTL) subsets (Chensue et al., 1981; Weinstock and Boros, 1983; Ragheb and Boros, 1989; Fidel and Boros, 1990). Here, CD8A is linked to Granuloma.