For instance, in Caucasian patients with advanced CRC who are treated with oxaliplatin, 5FU and leucovorin (LV), excision repair cross-complementation 1 (ERCC1) codon118 T/T, X-ray cross-complementing1 (XRCC1) (Arg→Gln substitution in exon 10), excision repair cross-complementation 2 (ERCC2) codon 751 A/C and ERCC2 codon 751 C/C genotypes are independently associated with poor progression-free survival and short-term survival [12,13]. The gene discussed is ERCC1; the disease is colorectal carcinoma.