In the present study, three polymorphisms located in DNA-repair genes (ERCC1 and XPD) and cell proliferation and differentiation related gene (EGFR) were assessed in 257 Taiwanese CRC patients who underwent potentially radical curative surgery using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) technique and DNA sequencing. The gene discussed is EGFR; the disease is colorectal carcinoma.