UNC93B1 and viral infectious disease: Mice homozygous for a nonfunctional Unc93b1 (H412R) allele (Unc93b13d/3d) fail to respond to TLR3, TLR7, or TLR9 ligands, and mice and humans deficient in UNC93B1 are highly susceptible to viral infection (Casrouge et al., 2006; Tabeta et al., 2006; Lafaille et al., 2012).