PROK1 and hepatocellular carcinoma: The AMELY-activated upstream regulation molecular network included BUB1B, CST6, ESM1, HOXA5, LEF1, MAPT, MYBL2, NOTCH3, PLA2G1B, PROK1, ROBO1, SCML2 and UBE2C in HCC, as shown in Fig. 2.