Therefore, our results support the notion that HA promotes tumor progression mediated by other receptors such as the receptor for HA-mediated motility (RHAMM), lymphatic vessel endothelial receptors (LYVE-1), and toll-like receptors 2 (TLR2) and 4 (TLR4) in canine mammary tumor. This evidence concerns the gene TLR2 and breast cancer.