The overexpression of SRF in cancer has increasingly been shown to enhance invasion and migration of cancer cells, due to loss of cell-cell adhesion (6), acceleration of cell migration and invasion in hepatocellular carcinoma, and acquisition of mesenchymal phenotypes due to the expression of a mesenchymal marker (vimentin) and the activation of immediate early genes (10,11). The gene discussed is SRF; the disease is hepatocellular carcinoma.