In a study on a large cohort of Saudi PTC patients (23), OBRs and leptin were found to be expressed in 80.1% (410/512) and 49.1% (252/513) of PTC patients, respectively, and OBR expression was strongly associated with age, gender, extrathyroidal extension, tumor stage, tumor size, node metastasis and histological type. This evidence concerns the gene LEP and neoplasm.