Tocilizumab (Actemra, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan), a humanized anti-human IL-6 receptor (IL-6R) monoclonal antibody that inhibits IL-6 binding to IL-6R might inhibit the biologic function of IL-6, which plays a pivotal role in the pathogenesis of autoimmune diseases. This evidence concerns the gene IL6 and autoimmune disease.