ERBB2 and breast carcinoma: A second paper published by Ferrario et al. [6] showed that combined treatment of IT trastuzumab and thiotepa is a promising and safe approach; this conclusion was based on the observation of 31-year-old woman with HER2-positive breast cancer treated with increased doses of IT trastuzumab and then IT trastuzumab with thiotepa (see Table 1).